(U.S. Food and Drug Administration/Public domain)

Six-month implant newest option to treat addiction amid opioid crisis

B.C. has been the hardest hit by opioid-linked deaths in the past two years

Canadians addicted to opioids may be eligible for an implant that provides an ongoing low dose of medication for six months, with the potential for treatment for up to a year when a new implant is placed in the opposite arm.

The procedure involves trained physicians inserting match-stick sized rods under the skin of the upper arm, each containing the medication buprenorphine.

Health Canada approved the implant in April 2018, two years after it was granted approval in the United States. It is marketed under the brand name Probuphine and is the first such implant for the treatment of addiction to opioids.

Dr. Seonaid Nolan, a clinical researcher with the BC Centre on Substance Use and an addiction medicine physician at St. Paul’s Hospital in Vancouver, said the implant is another treatment option alongside medications including Suboxone, the recommended treatment for an opioid addiction, followed by methadone.

“It’s so important to have a number of treatment options because there’s no one-size-fits-all for turning the tide on the opioid crisis,” said Nolan, who is also medical director of the addiction program at Providence Health Care.

The implant’s main advantage is that it eliminates barriers such as patients having to remember to take daily tablets of Suboxone, which can be a particular challenge for those entrenched in addiction while battling issues such as poverty, lack of housing and unemployment, she said.

The implant would also do away with the need for patients to take a drug under supervision, at least initially, in order to ensure compliance and deal with risks of it being diverted or misused.

Nolan said one addiction-medicine doctor at St. Paul’s Hospital has been trained on how to insert the implant, considered a viable option for people being released from correctional facilities, residential treatment programs and prolonged hospital stays because their tolerance to illicit opioids would be markedly reduced, putting them at higher risk of overdose.

The Canadian Agency for Drugs and Technologies in Health, which reviews all drugs and devices approved by Health Canada, said in a statement it has recommended provincial drug plans reimburse the cost of the implant for patients who have been stabilized on no more than eight mg of buprenorphine, in conjunction with counselling.

The agency’s drug-expert committee says the cost of the implant should not exceed the total drug plan cost of buprenorphine at a dose not exceeding eight milligrams a day.

The Health Ministry in British Columbia, the hardest-hit province in the overdose crisis, with more than 3,000 fatalities over the past two years, said the province’s independent Drug Benefit Council is conducting its own review of the implant before it determines whether the cost will be covered.

Montreal-based Knight Therapeutics licensed the implant from a U.S. company to commercialize and distribute it in Canada.

Knight Therapeutics president Samira Sakhia said the cost would be $1,495 per implant, equivalent to six months of treatment on Suboxone.

The company has trained doctors in major Canadian cities on how to insert the implant, she said.

“We are early in our launch. What we’re trying to do is make sure that if a physician has a patient who they feel would benefit from Probuphine what we would do is co-ordinate with that physician so that if they’re not trained they have access to someone who is trained and is close enough to them and their patient.”

READ MORE: B.C. opioid overdoses still killing four people a day, health officials say

READ MORE: Health Canada warns against giving opioid-containing cough, cold meds to youth

Sakhia said one patient, in the Maritimes, has so far received the implant in Canada.

“It’s a complicated product because of the nature of it being an implant and we are trying to do what we can to make sure that physicians are trained, knowledgeable, and we’re working towards reimbursement because that will make access easier.”

Camille Bains, The Canadian Press


Like us on Facebook and follow us on Twitter.

Just Posted

LETTER: Emergencies can wait on Sasquatch Mountain

Hemlock Valley resident Andy Ibbetson writes about his concerns on the new E-comm 911 service

Semi truck crashes into highway barrier cable near Chilliwack

Witnesses warning other drivers to watch for debris in other lanes

Multi-vehicle collision on highway in Chilliwack

Accident involves several vehicles, in the westbound lanes says Drive BC

Age nothing but a number for women in Fraser Valley 7-a-side soccer league

Rockers’ soccer 7-a-side league is for women 30 and older

Agassiz bus driver’s seatbelt petition heads to Ottawa

Gary Lillico is hoping his one-month petition will make a mark on the House of Commons

VIDEO: Quadriplegic man takes flight over Harrison Mills

Jim Ryan hasn’t moved his arms or legs for three years, but that didn’t stop him from paragliding

On-duty Vancouver police officer facing dangerous driving charges

Few details have been provided about the case

Oil companies, 24-cent gap between B.C., Alberta to be focus of gas price probe

Premier John Horgan called the spike in gas prices ‘alarming’

Growing coffee, tea, lemons and papayas in the Fraser Valley

‘Anything that is grown anywhere on the planet we can grow’

Motorcycle deaths spike 50% since 2017

Riders were most likely fatally crash on the weekends compared with the rest of the week

Mother of accused charged in death of Surrey teen girl found in torched SUV

Manjit Kaur Deo charged with ‘accessory after the fact’ in 2017 death of Surrey teen

5 to start your day

Corgis put on a show at the Cloverdale Rodeo, family of B.C. pilot killed in Honduras remembers him and more

Family of B.C. pilot killed in Honduras trying to ‘piece together’ tragedy

Patrick Forseth has a number of friends in the area and was loved by everyone

Justin Trudeau credits immigration for Canada’s growing tech sector

Trudeau stressed that Canada has become a major source of talent for tech all over the world

Most Read